What could be the possible reasons of IVF failure ?

An interesting article by IVF specialists of the best IVF centre in Delhi – Gunjan IVF World on what might lead to IVF failures.

In-Vitro Fertilisation or IVF has become one of the most preferred assisted reproductive techniques among couples who have been facing difficulty conceiving naturally. IVF is a process in which a woman is made to produce more eggs through ovarian stimulation, which are fertilised with her partner’s sperm in a laboratory under controlled environment. The embryo formed from the fertilisation is then transferred into the woman’s uterus. If everything goes well, there will be a successful pregnancy. Gunjan IVF World, the best IVF center in Ghaziabad through this interesting blog shares the possible reasons that lead to IVF failures.

“IVF is a blessing for couples who have been unsuccessful at conceiving naturally. Studies reveal that almost 2.5 million IVF cycles are performed every year resulting in over 5,00,000 deliveries only. Every stage of the IVF process is crucial and hence, needs to be well-monitored and managed,” says Dr. Gunjan Gupta, leading IVF specialist Ghaziabad and Founder & Director, Gunjan IVF World – a well-know IVF center in Delhi with three more state-of-the-art clinics in Indirapuram, Meerut and Noida (commencing soon).

Patients often find it difficult to understand the reason of failure. They question that when eggs and sperm are fertilised in a laboratory and only a healthy embryo is transferred to uterus, what could be the reason behind the procedure being unsuccessful. “At Gunjan IVF World, we explain the procedure to our patients well in advance and keep them informed at every stage of their treatment. We tell them that like most biological events, pregnancy too is a very complex process and there could be various reasons behind the failure of an IVF cycle. It is important to be patient, identify the reason, look for a possible treatment to increase the chances of a successful pregnancy,” says Dr. Aastha Raheja, Consultant at the best IVF centre in Ghaziabad.

So, let’s take a closer look at some of the possible reasons why IVF can fail.

Quality of eggs: It is a known fact that a healthy egg can give birth to a healthy embryo. Any abnormalities or anomalies in the egg can lead to chromosomal abnormalities in an embryo. “Age plays a big role in the success of an IVF cycle. With growing age, the free radicals in a woman’s ovaries increase. These radicals react with the eggs resulting in DNA damage which reduces the quality of eggs,” states Dr. Garima Sharma, Consultant & Centre In-Charge of Gunjan IVF World – a leading IVF center in Janakpuri.

Quality of sperm: Yes, you read it right. A man too can be responsible for the failure of IVF. Sperm abnormalities can also leave the egg unfertilised. In the fertilisation process, sperm is supposed to travel through the fallopian tube to the egg, penetrate the egg’s outer membrane, and release the sperm DNA to produce an embryo. So, it is important that high-quality chromosomally normal sperm are chosen and used during IVF for successful fertilisation.

Selection of embryo: The success of IVF depends a lot on the selection of the embryo too. “The uterus does not accept chromosomally abnormal embryos for implantation causing miscarriages or implantation failures. So, it is always better to do a thorough evaluation of the embryo health before implantation,” adds Dr. Anshu Dhar, Consultant of a renowned IVF clinic in Indirapuram – Gunjan IVF World.

Structural problems: The uterus plays an important role in IVF. It is where the
embryo implants and develops over the next nine months. Factors that can come
in the way of an unsuccessful implantation could include uterine age, hormonal
changes, any uterine infection, formation of adhesions, polyps or fibroids, thin
endometrial lining, thrombophilia, etc.

Genetic factors: The embryo in its development phase undergoes a series of cell divisions which can lead to anomalies like chromosomal translocations, deletions, mosaics, duplications, etc. Embryos that have abnormal karyotype often fail to
implant on the uterine wall.

Parental health: Health of the parents also plays an important role in IVF. Obesity, diseases like diabetes, hypertension can result in IVF failures. Lifestyle disorders like excessive consumption of alcohol, smoking, substance abuse can contribute to implantation failures.

Problems with embryo transfer: Embryo transfer is a very sensitive procedure and should be done with utmost care. Any changes in the procedure can result in a failure. Furthermore, the embryo needs to be transferred to the right location to ensure proper implantation.

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